Stemulite Fitness Formula for Men

Stemulite for Men is made from all-natural ingredients and contains several very effective, and targeted, natural proteins, enzymes and amino acids. R-Lipoic Acid ("R"-ALA): 300 mg R+ Alpha-lipoic acid occurs naturally in every cell of the body and is essential to the chemical reactions that allow our bodies to produce energy. As a supplement, it is rapidly absorbed into the blood and the cells where it can prevent free-radical damage. It is vital for the creation of energy in every organ of the body, but as we age, there is not enough of it in sufficient quantities. Alpha Lipoic Acid (ALA) (or thioctic acid) is sulfur containing saturated fatty acid found in small amounts in food. The reduced form is known as dihydrolipoic acid (DHLA), while the oxidized form is known as ALA. ALA is synthesized de novo from an 8-carbon fatty acid (octanoic acid) in mitochrondria, where protein-bound ALA functions as an enzyme cofactor. How it Works Each cell in our body comes equipped with its own energy mini-engine. This engine is called mitochrondria and ALA is essential to mitochrondial function. Mitochondria are cellular organelles that act like tiny engines to convert unusable forms of energy (sugar, protein, fat, amino acids, etc) into a usable chemical form known as adenosine triphosphate (ATP), so that vital cellular chemical reactions throughout the body can occur. They do this by oxidizing (burning) fuels, such as lipids from the diet, and transporting free electrons liberated from these oxidation reactions through a series of proteins called the "electron transport chain." An electrical potential develops across the inner mitochondrial membrane as a result of this movement of electrons. ALA increases the influx of lactate or pyruvate into mitochondrial with corresponding increased O2-*. Energy liberated from these oxidation reactions is then used as the driving force for ATP synthesis. It is clear that factors and conditions that cause mitochondrial dysfunction could severely affect overall cellular metabolism and ultimately, our energy levels and survival. Other Effects There is tantalizing evidence that mitochondrial decay may be a primary factor in the aging process. As already noted, mitochondria are the chief source of endogenous oxidants, including hydrogen peroxide and the superoxide and hydroxyl radicals. This high flux of oxidants would not only be expected to damage the cell overall, but also certainly would damage the mitochondria in which the oxidants are produced. Despite an impressive array of antioxidant defenses, such as vitamin C, glutathione and vitamin E, the level of oxidative damage to mitochondria is enormous. Experiments have shown that oxidative damage to mitochondrial DNA (the only organelle with its own DNA outside the nucleus) is 8 to 10-fold higher than the levels found in nuclear DNA and accumulates even higher levels of damage with age. Chronic steroid use in exercise training and body building often leads to prediabetic conditions or prediabetes. One hallmark of the insulin-resistant state of prediabetes and overt type 2 diabetes is an impaired ability of insulin to activate glucose transport in skeletal muscle, due to defects in insulin receptor substrate-1 (IRS-1)-dependent signaling. An emerging body of evidence indicates that one potential factor in the etiology of skeletal muscle insulin resistance is oxidative stress, an imbalance between the cellular exposure to an oxidant stress and the cellular antioxidant defenses. Therefore, anyone who has any kind of a chronic high glucose should daily take ALA. Exposure of skeletal muscle to an oxidant stress leads to a vicious cycle of impaired insulin signaling and subsequently to reduced glucose transport activity. Numerous studies have demonstrated that treatment of insulin-resistant animals and type 2 diabetic humans with antioxidants, including alpha-lipoic acid (ALA), are associated with improvements in skeletal muscle glucose transport activity and whole-body glucose tolerance. Weight Reduction Any overweight person who begins an exercise/ fitness program can reduce fat and improve fitness. Recent investigations have demonstrated that the combination of exercise training and antioxidant treatment using ALA in obesity-associated insulin resistance provides a unique interactive effect resulting in a greater improvement in insulin action on skeletal muscle glucose transport than either intervention individually. Moreover, this interactive effect of exercise training and ALA is due in part to improvements in IRS-1-dependent insulin signaling. These studies highlight the effectiveness of combining endurance exercise training and antioxidants in beneficially modulating the molecular defects in insulin action observed in insulin-resistant skeletal muscle. The insulin-like of effects of ALA provide body builders a powerful synergistic effect when used with creatine. "R"-ALA is prescribed in Germany to treat diabetic and alcoholic neuropathies and alcoholic liver disease, thought to result in part from free-radical damage. As discussed above, there is also evidence that it can help decrease insulin resistance; it speeds the removal of glucose from the bloodstream by enhancing insulin function, and thus helps control blood sugar, underlying many cases of coronary heart disease and obesity. Fitness /Training Applications For Weight Lifting - Body Building - Elite Athletes - & Individuals who Workout regularly: Powerful Antioxidant and mimics insulin Enhances Glucose Utilization Enhance Amino Acid Transport Lowers Blood Sugar Increases Creatine Uptake ALA increases your muscles uptake of glycogen. This increases muscle cell volume and contributes to that full pumped feeling when you workout. This is a very desirable effect as the increase in muscle glycogen also increases other important nutrient transport that contributes to cell volume and muscle growth. ALA is not a thermogenic but it does appear to contribute to favorable body composition changes. This is believed to be due to a nutrient partitioning effect where nutrients are channeled more too lean tissue and away from fat tissue. ALA will help enhance the efficiency of many different supplements and pharmaceuticals. It enhances the absorption of creatine into the muscle cell by providing a transport vehicle by its unique ability to mimic insulin. ALA is also one of the most potent antioxidants available. And, when taken with other antioxidants it actually enhances their antioxidant abilities. Aminocarnitine (L-carnitine amino acid): 200 mg L-carnitine, an amino acid derivative, is found in nearly all cells of the body. L-carnitine transports long-chain fatty acids across the inner mitochondrial membranes in the mitochondria, where they are processed by beta-oxidation to produce biological energy in the form of adenosine triphosphate or ATP. L-carnitine is one of the neurotransmitters that cross the blood-brain barrier and functions to support mental clarity and memory. L-carnitine is also known as levocarnitine and was formerly called vitamin BT. L-carnitine is a quaternary amine and belongs to the same chemical family as choline and is soluble in water. L-carnitine occurs naturally in animal products. Generally, only very small amounts of it are found in plants, with few exceptions, such as avocado and some fermented soy products, e.g. tempeh. L-carnitine is a chiral molecule. Its stereoisomer D-carnitine does not have the biological activity of L-carnitine and may even antagonize L-carnitine in its biological roles. L-carnitine is synthesized in the human body, chiefly in the liver and kidneys, from the essential amino acids L-lysine and L-methioine. Niacin, vitamins B6 and C, and iron are involved in its biosynthesis. L-carnitine is described as a conditionally essential nutrient. This refers to certain conditions where exogenous L-carnitine may be required, such as in long-term parenteral nutrition, that on valproic acid therapy and possibly for the elderly. How it Works There are at least two major functions of L-carnitine. All tissues except the brain use long-chain fatty acids for bioenergy production. In cardiac and skeletal muscle, a major contribution of bioenergy comes from the beta-oxidation of long-chain fatty acids. Long-chain fatty acids require L-carnitine to transport them across the inner membranes of the mitochondria, wherein their metabolism produces bioenergy. Following the delivery of long-chain fatty acids into other mitochondria, L-carnitine, either by itself or esterified to an acyl group, recrosses the mitochondrial membrane to allow for continual use in this shuttle process. Another function of L-carnitine is to remove short-chain and medium-chain fatty acids from the mitochondria in order to maintain coenzyme A levels in these organelles. These fatty acids accumulate as a result of normal and abnormal metabolism. This mechanism prevents the build-up in the mitochondria of short-chain and medium-chain fatty acids that may interfere with the bioenergy-producing process vital to the normal function of the cell. As mentioned above, L-carnitine is a neurotransmitter which crosses the blood brain barrier. Neurotransmitters are essential in mental processing, memory and concentration. Synergistic Effects Alpha lipoic acid and acetyl L-carnitine: could alpha lipoic acid and acetyl L-carnitine combine to form the Elixir of Life? When ALA is combined with L-carnitine the effect is powerfully synergistic. The initial excitement about ALC/alpha lipoic acid (ALA) supplementation began when a team of researchers in California fed elderly rats both nutrients for a period of seven weeks and then compared them with young rats. They were testing the theory that mitochondrial decline is caused by free radical damage. There was already evidence that supplementation with acetyl L-carnitine (ALC) could reverse the age-related decline in mitochondrial activity in rats, increase fatty acid oxidation and boost general metabolic activity. However the down side to this increased mitochondrial function was that more oxidative damage occurred, so the researchers decided to add the powerful mitochondrial antioxidant alpha lipoic acid (ALA) to the mix to see if they could get the best of both worlds: increased mitochondrial energy output, with reduced mitochondrial damage. This two-pronged ?punch' to ageing cells seemed to work, with the two supplements together producing better results than either one alone. After a month on the supplements, elderly (24-month-old) and lethargic rats had more energy and did better on memory tests, while their mitochondria worked better. The decline in overall activity typical of aged rats was reversed to the level of young-to-middle-aged adult rats, aged 7-10 months. The researchers likened this result to a group of 80-year-old humans throwing away their walking sticks and starting to act 35 years younger! Other Implications for Human Health These studies on rats caused a huge stir within the scientific community. Here was evidence that some of the processes of ageing could be slowed or even reversed, and the implications for human health and performance were enormous. In the months that followed, a number of human studies were started, many of which are still under way. However, the question of whether the benefits observed in rats might also apply to humans will not be easy to determine. For one thing, the ageing process in humans is much slower than in rats, so the seven-week supplementation period used in the rat studies would equate to around five years of supplementation in humans! Secondly, the amounts of acetyl L-carnitine (ALC)/alpha lipoic acid (ALA) used in the rat studies were very high - equivalent to 50g per day of acetyl L-carnitine (ALC) and 5g of alpha lipoic acid (ALA) for an 150 pound adult. That's around 50 times more than is typically available in acetyl L-carnitine (ALC)/ALA supplements found on the shelves of most health food stores! One of the earliest studies examining the effect of acetyl L-carnitine (ALC) and alpha lipoic acid (ALA) in humans was carried out at San Francisco State University in 2001. In a double-blind, placebo-controlled study lasting 17 weeks, 18 healthy sedentary men aged 60-71 were randomized to one of two treatment régimes: a placebo tablet twice a day or 1,000mgs of acetyl L-carnitine (ALC) and 400mgs of alpha lipoic acid (ALA) in two divided doses. Both groups were then asked to perform a demanding sequence of exercises, after which blood was drawn and analyzed for signs of exercise-induced oxidative stress (a potentially damaging by-product of energy production). To measure oxidative stress, the study evaluated nine different biomarkers: ammonia, beta-carotene, glutamine, glutathione, malondialdehyde, total antioxidant status (TAS), vitamin C, vitamin E-alpha tocopherol, and vitamin E-gamma tocopherol. For eight of these nine biomarkers, a majority of subjects in the treatment group recorded values indicating that levels of oxidative stress had fallen. By contrast, no such benefits were reported in the placebo group. Fitness/Training Applications If an acetyl L-carnitine (ALC)/alpha lipoic acid (ALA) combination can reduce exercise-induced oxidative stress that would be good news for athletes, who are particularly vulnerable to such stress. However, because the small scale of this study made it difficult to reach statistically significant conclusions, the results were not submitted for scientific publication, which means they should be interpreted with caution. Other human studies are also currently under way, but so far there are no published human studies available, although positive studies in animals continue to proliferate. Last year, for example, American researchers demonstrated that alpha lipoic acid (ALA) supplementation in older racehorses reduced the oxidative stress burden even under light training loads, while a number of other animal studies have shown that acetyl L-carnitine (ALC)/ALA supplementation reduces oxidative stress and improves mitochondrial function in a number of tissues, including brain, muscle and heart. In one of these studies, researchers examined the effects of acetyl L-carnitine (ALC)/alpha lipoic acid (ALA) therapy on ageing and hearing in rats, and found that it reduced the normal age-associated deterioration in auditory sensitivity and improved inner ear function. They concluded that these improvements were related to the acetyl L-carnitine (ALC)/ALA combination's ability to protect and repair age-induced mitochondrial DNA damage, thereby boosting mitochondrial function and improving energy turnover. However, while the initial evidence from animal studies looks extremely promising, the jury is still out as far as humans are concerned. Beta Glucan: 50 mg B-Glucans (or beta-glucans) are both soluble and insoluble natural gum polysaccharides (sugars) occurring in mushrooms, barley, oats and to a lesser degree in rye and wheat. They are thought to have extensive use or potential in many medical and human nutritional applications. The sugars are branched from a protein backbone molecule which has myriad configurations. The beta glucan used in Stemulite? is a 1, 3-1, 6-beta glucan derived from edible mushrooms. Beta-glucans found in certain such as mushroom fungi are thought to have anticancer properties. In Japan, mushroom-derived extracts rich in beta-glucans have been used for over 20 years in intravenous forms and are approved for use as adjuncts to chemotherapy. There is a phase III trial in the U.S. using beta-glucans with other cancer drugs. No forms of beta-glucans have been approved by the FDA to treat cancer. Since beta-glucan activates complement in the immune system it can be used as a potent recruiter and mobilizer of stem cells from the bone marrow. These progenitor cells have the unique ability to differentiate into any cellular tissue in the body. How it Works The immune system responds to cell signals that identify "self" from "non-self" (a germ or virus is considered non-self) by the release of complement. The insoluble Beta-glucan has the unusual ability to enter the blood stream via the Peyer's patches in the gut and activate the immune system's complement component regardless of whether or not the body is invaded by germs or viruses. Complement is a protein that affects only non-self organisms. The white cells of the body are mobilized to attack infections and disease and are guided by antibodies released by B-cells. Obviously, daily use of foods or supplements containing beta-glucan can maintain a heightened immunity to all disease. When beta-glucan activates the body's complement system such as CR3 receptors on stem cells, they are up-regulated to bind with certain growth factors released by injured tissue. These factors act as powerful signals to recruit somnambulant progenitor stem cells in the body to mobilize and migrate to certain disease or injured tissues in order to repair (and in the case of stem cells) or replenish the injured or dysfunctional cell population. Once stem cells become resident of a tissue system (such as a muscle group) or organ they quickly multiply and replace old tissue with new juvenile cells which are able to mature in a matter of hours or days into the same tissue type that was earlier dysfunctional. If the genetic component of the tissue is normal, the new cells continue replicating indefinitely, completely and perminately eradicating the problem. In the case of fitness training, the stem cells are recruited in great numbers to mobilize in muscle systems replacing fat and adding brand new muscle. Synergist Effects Beta-glucan and lipoic acid both participate in the processes of cell growth and differentiation. The process then may become accelerated much in the same manner as steroids effecting muscle growth and inflammation. This has enormous implications in improvement in human health and fitness. A healthy and enhanced immune system provides the body with continual surveillance and immediate defense against disease. Fitness/Sports Applications The immune-stem-cell health potential in fitness and body building is enormous. Over 200,000 cases of tendons tears are treated by physicians annually in the United States. Millions of fitness buffs are constantly slowed or hindered by sprains and muscle pulls which interrupt the training regimes. Within professional sports, injured athletes can incur staggering financial loss. Stem cell recruitment and anti inflammatory action by a beta-glucan/lipoic acid/acetyl carnitine combination may be able to drastically reduce both the injuries and the recovery time of such injuries. SerraPeptase? (Serratiopeptidase): 50 mg SerraPeptase? is a proteolytic (breaks down waste proteins) polypeptide enzyme isolated from the non-pathogenic bacteria Serratia species found in the digestive tract of the Japanese silkworm. The enzyme is used by the cocoon-forming silkworm butterflies mature to digest their cocoons. Serrapeptase has been used as a nutritional supplement in Europe and Asia for nearly three decades. How it Works SerraPeptase flushes off congregated waste protein and naturally eases minor pain and inflammation form overexertion or everyday activities by breaking down extraneous fibrin, mucus and other inflammatory compounds the congregate when the body's natural repair function are working. It supports the body's natural process for both drainage and repairs and therefore thought to be extremely helpful in supporting cardiovascular health. Fitness/Training Applications This product can be taken in the supplement as a preventative before an athletic event to allow the body to immediately begin repair from inflammation caused by extreme workouts or physical traumas. It enters inflamed areas that have been isolated from the body's circulation, caused by sprain, swelling, or bruises allowing for recovery time to be greatly accelerated. Therefore it is very useful for athletes who incur any type of muscle damage. Quercitin: 50 mg. Quercitin belongs to a group of polyphenolic substances known as flavonoids. Quercitin is a member of the class of flavonoids called flavones. It is widely distributed in the plant kingdom in rinds and barks. Especially rich sources of Quercitin include onions, red wine, green tea and St. John's wort. Quercitin is typically found in plants as glycone or carbohydrate conjugates. Quercitin itself is an aglycone or aglucon. That is, Quercitin does not possess a carbohydrate moiety in its structure. Quercitin glycone conjugates include rutin and thujin. Rutin is also known as quercetin-3-rutinoside. Onions contain conjugates of Quercitin and the carbohydrate isorhamnetin, including quercetin-3, 4'-di-O-beta glucoside, isorhamnetin-4'-0-beta-glucoside and quercetin-4'-0-beta-glucoside. Quercitin itself is practically insoluble in water. The Quercitin carbohydrate conjugates have much greater water solubility than Quercitin. Thus, daily Quercitin conjugation with other carbohydrates in the body may produce mild diuretic effects. This benefit is especially in women's fitness as monthly menses usually produces a short period of fluid retention (plumping out) and a diuretic would help maintain body definition. How it works Quercitin has antioxidant, anti-inflammatory, antiviral, immunomodulatory, anticancer and gastroprotective activities. It appears also have anti-allergy activity and activity in preventing secondary complications of diabetes. Quercitin is an antioxidant and has been shown to inhibit lipid peroxidation. The putative anti-ulcer and gastroprotective effects of Quercitin may, in part, be accounted for by this activity. In vitro and animal studies have shown that Quercitin inhibits deregulation of inflammatory mast cells, basophiles and neutrophils. Thus, quercitin, a special bioflavonoid antioxidant shown to have an antihistamine effect in the body, makes it a natural putative for anti-inflammatory, anti-allergy and immunomodulating activities. Fitness/Training Applications Quercitin adds synergy to the anti inflammatory effects of ALA, SerraPeptase, and Beta glucan reducing recovery time after hard workout. This helps keep airways open and clear of excess mucus. As discussed above, Quercitin is prescribed in Europe as a mild diuretic, and when used in training should prevent fluid accumulation in other body tissues. Melatonin: 2 mg. Melatonin is the principal hormone of the vertebrate pineal gland, and it is also produced by extra-pineal tissues in amphibians. It is found in plants as well, but at much lower concentrations than in animals. This hormone is involved in setting the timing (entrainment) of mammalian circadian rhythms, as well as regulating seasonal responses to changes in day length in seasonally breeding mammals?so called photoperiodic responses. Photoperiodic responses include changes in reproductive status, behavior and body weight. Seasonal effects on reproduction in humans are subtle, and the role of melatonin here, if any, is unclear. Recently, melatonin supplementation has become popular as an aid for sleep disorders among other things. How it works Melatonin is synthesized by the pineal gland in the midbrain. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. In this synthesis, L-tryptophan first gets metabolized to 5-hydroxytryptophan from which 5-hydroxytryptamine, also known as serotonin, is made. 5-hydroxytryptamine is converted to melatonin in a two-step process, occurring mainly in the pineal gland. Melatonin promotes rapid eye movement (REM) sleep and circadian rhythms that regulates the metabolism of all higher organisms. In man, the body shifts into a quiescent state during sleep which facilitates cellular repair and rebuilding of body tissues. When awake the body operates its metabolism at a much higher rate than when sleeping. Blood pressure, heart rate, breathing, and brain activity operate at a much higher rate requiring most of the available energy of the body. This heightened activity leaves little energy for replenishing vital protein, nutritional, cellular repair, and hormone stores for vitality, down regulation of localized inflammatory states, muscle growth and cellular repair which are necessarily carried out during sleep. This is why sleep is so vital to the maintenance of good health. During sleep the liver, kidneys, and other organs typically detoxify the accumulation of ingested, internally manufactured, and inhaled toxins. As heart rate slows and blood pressure drops during sleep, the pressure differential in the extra-cellular spaces allow the cells to expel toxins from the cytoplasm into the interstitial spaces where the lymph and venous systems pick them up and carry them to liver, kidneys and gut for elimination. When one dreams in what is called REM sleep, the body is actually in a paralytic state, unable to move. A great deal of emotional adjustment and brain repair is carried out in REM sleep. Fitness/Sports Applications One of the most important aspects of proper performance (and one of the least practiced) is the concept of regular sleep patterns. Athletes are notorious for working their bodies extremely hard, and not getting the required sleep they need for proper performance. This is seen in a multitude of high school athletes who never make it through intercollegiate sports, and college athletes who do not continue after university sports. Dancers, and some professional athletes who have hectic travel schedules, who disregard the importance of sleep also limit their longevity in their sports. REM sleep, Eggplant Extract: 10 mg Eggplant is a member of the Solanaceae family, which includes some of the most nutritious plants--potato, eggplant, tomato. It contains a powerful alkaloid which acts as an agonist on the acetylcholine (AChR) receptor which when activated is the most effective stem-cell and growth factor combination yet discovered. How it Works With the discovery of the adult stem cell found in the bone marrow of adults by Catherine Verfaillie at the University of Minnesota in 2002 it became obvious that stem cells carried an enormous potential to accelerate and enhance the building of new muscle and other tissues in the human body. John Cooke, et al., of Stanford University later identified a specific agonist and receptor for adult stem cells and demonstrated a mechanism of action for the de novo building of blood vessels in blood-starved limbs of animals. If followed that not only blood vessels but any tissue theoretically could be built or be remolded with adult stem cells. Eggplant alkoloids binding the acetlycholine agonist receptor enhances cognitive functions, such as learning, memory, and retention through activation of brain nicotinic acetylcholine receptors (nAChR). The most common nicotinic receptors found in the brain are the low affinity a 7-nAChR and the high affinity a 4b2-nAChR. a 7- and a 4b2- nAChR agonists possess cognitive-enhancing properties. Several large pharmaceutical companies are developing alpha 7 agonist binding agents. Target treatments include stem-cell activations and recruitment, Parkinson Disease, Schizophrenia and Alzheimer's. Fitness/Training Applications: Two new types of stem cells have been found that can seek out injured muscle tissue and replace the damaged cells. Both types respond to the alkaloids found in eggplant extract. Researchers in Italy used stem cells from blood vessels to repair muscle in mice with muscular dystrophy. Canadian scientist found that stem cells from damaged muscle give rise to new muscle fibers. The studies reveal how different typed of stem cells repair injured muscle and point to common: Damaged tissue sends out molecular signals that attract new stem cells. The stem cells then multiply and form new muscle fibers, replacing and repairing injured tissue. Until recently the signals that recruit stem cells to sites of injury have been unknown. Understanding these signals seems to be the key to finding new ways to replace damaged tissues by encouraging the growth of stem cells already in the body. Athletes should also be interest in these finding, which lend credence to the "no pain, no gain" approach to strength training and may lead to new strategies for bulking up. Researchers found that stem cells from normal tissue would not multiply in culture, but those isolated from injured muscle readily proliferated and gave rise to new muscle cells. Mental acuity and sharpness are required in almost all sports. Stem cell recruitment combined with exogenous ingestion of natural alkaloids that bind and activate the alpha 7 AChR receptors in the brain and promote clarity and mental concentration.