EPO-BOOST™ safely stimulates your body's natural production of the erythropoietin (EPO) hormone. EPO increases the body's oxygen carrying capacity and has been shown in controlled human clinical studies to significantly increase athletic performance and endurance.
EPO Production
Echinacea Purpurea: Echinacea is an herb that stimulates your immune system and your kidneys to make more EPO. In the long run, this results in more red blood cells.and peak performance.
Four capsules of EPO-BOOST™ endurance supplement provides 8 grams of echinacea purpurea, an amount shown to significantly increase EPO production in athletes.
Red Blood Cell Nutrients
To help your body produce more red blood cells, it needs the raw materials to make them. That's why scientists developed a specific formula of vitamins and minerals that ensure additional EPO results in extra RBCs.
Here's how certain vitamins and minerals can bolster red blood cell production:
Vitamin B-6 (Pyrodixine): A red blood cell is useless without hemoglobin. That's because hemoglobin is the part of a red blood cell that oxygen attaches to. Research published in the Journal of Biological Chemistry discovered that vitamin B6 is essential for hemoglobin to form. In other words, if you don't get enough vitamin B6, your red blood cells can't carry the oxygen you need.
B-12 and Folic Acid: If you're deficient in either vitamin B12 or folic acid, new red blood cells are "born" misshapen and malfunctioning. This can actually make oxygen transport worse than before. That's why you need to get supplemental doses of both B12 and Folic Acid. If you do, your new red blood cells become the hard-working oxygen carriers they are supposed to be.
Vitamin B-3: Here's another vitamin that your body needs in order to pump out new, healthy red blood cells. A daily dose of Vitamin B-3 helps your body produce new red blood cells at a faster clip.
Boron: Boron might not get a lot of press, but it's emerging as a mineral that can help athletes of all kinds. Its beneficial effects stem from the fact that boron can naturally help your body make more red blood cells than it could without extra Boron.
Inositol: You may be making more red blood cells, but it doesn't mean that they'll last. In fact, the lifespan of red blood cells is about 90 days. By taking inositol you'll be creating stronger red blood cells - making them work longer for you.
Iron Availability Complex
In reality, oxygen doesn't bind directly to the red blood cell - it binds to the iron in hemoglobin in the red blood cell. Therefore, you need several sources of dietary iron to make functioning red blood cells.
Iron: Proper iron intake ensures that red blood cells properly carry oxygen around the body. It's been shown in over 4,000 research studies that iron deficiency impairs oxygen transport and athletic performance. In fact, iron isn't an ingredient that's merely optimal for enhancing endurance - it's absolutely necessary.
Dandelion and Yellow Dock: To get even more iron, it's important to take these natural botanical extracts from two of the most iron-dense plants known to man: dandelion and yellow dock. These two herbs ensure that your body gets enough iron for its brand new red blood cells.
Vitamin C, Vitamin B3, and Nickel: It's one thing to take extra iron, but absorbing it from the gut is something else altogether. Believe it or not, but your body only absorbs about 10% of the iron that you eat. That is, unless you supplement with vitamin C, vitamin B3 and Nickel - a trio of nutrients that help your body absorb more of the iron that you consume.
Anti-Inflammatory Complex (Antioxidants)
After a particularly tough workout or event (aren't they all?), your body has taken a big hit. Its muscles are worn and torn, your energy reserves are depleted, and your joints are flaring up from stress and strain. Your body has one, and one way only, of dealing with all of this: inflammation.
Although inflammation is essential for recovery in small doses-unchecked inflammation makes recovering a real challenge. If you've ever had a period of time where your training suffered and it took you forever to bounce back, it's likely that inflammation was the culprit.
Worse yet, unchecked inflammation makes your body more prone to oxidation - a harmful process shown to get in the way of new muscle growth and adaptation to training. Not only that, but inflammation and oxidation can be roadblocks to new red blood cell development - causing a vicious cycle that puts the brakes on your progress.
Luckily, there are a handful of nutrients that are able to combat exercise-induced oxidation and inflammation; allowing you to get back on your feet and increase your EPO production.
Alpha Lipoic Acid: Let's be honest, there are thousands of antioxidants out there. The thing is the vast majority haven't been tested on athletes. This can't be said for Alpha Lipoic Acid (ALA).
A clinical research study published in The Journal of Physiological Sciences found that ALA was able to plummet oxidation and inflammation in athletes under intense training conditions. ALA does double duty for your body by fighting both inflammation and oxidation. So you'll be doing your performance a huge favor by including ALA in your supplement regimen.
Lutein: Lutein has been studied in an astounding 1,000 published research articles. That's because lutein is one of the most powerful antioxidants known to man. In study after study, lutein has effectively fought oxidation and inflammation all over the body.
Lycopene: Like lutein, lycopene has been intensely researched. Lycopene, found in tomatoes, fights oxidation through a number of different pathways. This makes it a preferred antioxidant for elite athletes.
Choline: Choline is an amazing antioxidant. Not only does it fight oxidative damage, but according to a study out of the University of Lisbon, it actually improves blood flow and nitric oxide (NO) production. In case you didn't know, nitric oxide is one of the most important chemicals in your body for improving muscle contraction and increasing blood flow to muscles.
PABA: Along with its trademark antioxidant properties, PABA is able to make blood vessels more fluid - helping blood (and oxygen) travel to your fatigued muscles.
The following peer-reviewed studies support the safety and effectiveness of the Epo-Boost™ formula.
Erythropoietin Production
Ingredient: Echinacea pupurea
1. Running economy and maximal oxygen consumption after 4 weeks of oral Echinacea supplementation. Whitehead et al. (2012) J Strength Cond Res. 26:1928-33
Department of Physical Therapy, Arkansas State University, State University, Arkansas, USA. twhitehead@astate.edu
Abstract
The purpose of this investigation was to determine the effects of 4 weeks of oral Echinacea (ECH) supplementation on erythropoietin (EPO), red blood cell (RBC) count, running economy (RE), and VO2max. Twenty-four men aged 24.9 ± 4.2 years, height 178.9 ± 7.9 cm, weight 87.9 ± 14.6 kg, body fat 19.3 ± 6.5% were grouped using a double-blind design and self-administered an 8,000-mg·d(-1) dosage of either ECH or placebo (PLA) in 5 × 400 mg × 4 times per day for 28 days. Blood samples were collected and analyzed for RBCs and EPO using automated flow cytometery and enzyme-linked immunosorbent assay. Maximal graded exercise tests (GXTs) were administered to measure VO2max, RE, and heart-rate responses. Analysis of variance was used to determine statistically significant differences (P ≤ 0.05). The EPO increased significantly in ECH at 7 days (ECH: 15.75 ± 0.64, PLA: 10.01 ± 0.73 mU·ml(-1)), 14 days (ECH: 18.88 ± 0.71, PLA: 11.02 ± 0.69 mU·ml(-1)), and 21 days (ECH: 16.06 ± 0.55, PLA: 9.20 ± 0.55 mU·ml(-1)). VO2max increased significantly in ECH (ECH: 1.47 ± 1.28, PLA: -0.13 ± 0.52%). Running economy improved significantly in ECH as indicated by a decrease in submaximal VO2max during the first 2 stages of the GXT (stage 1: ECH -1.50 ± 1.21, PLA 0.60 ± 1.95%; stage 2: ECH -1.67 ± 1.43, PLA 0.01 ± 1.03%). These data suggest that ECH supplementation results in significant increases in EPO, VO2max, and running economy.
2. ECHINACEA INCREASES ERYTHROPOIETIN, VO2MAX, AND RUNNING ECONOMY
4 capsules of EPO-BOOST® provides 8 grams of echinacea purpurea
Whitehead M. T., Martin T. D., Webster M. J., & Scheett T. P. (2007). Improved running economy and maximal oxygen consumption after 4-weeks of oral Echinacea supplementation. ACSM Annual Meeting New Orleans, Presentation Number, 908.
PURPOSE. This study investigated the effects of four-weeks of oral Echinacea supplementation on erythropoietin, running economy, and VO2max. Males (N = 24) were supplemented with either 8,000 mg/d of Echinacea purpurea (N = 12) or a placebo (N = 12). Blood samples were collected prior to and every seven days during supplementation and analyzed for erythropoietin. Maximal graded exercise tests were administered to measure VO2max, running economy, and heart-rate responses.
RESULTS. The Echinacea condition significantly increased Erythropoietin at days 7, 14, and 21 and VO2max. Running economy improved significantly in the Echinacea condition (indicated by a decrease in submaximal VO2 during the first 2 stages of the graded exercise test).
CONCLUSION. Echinacea purpurea supplementation results in significant increases in erythropoietin, VO2max, and running economy.
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3. Whitehead, M. T., (2006). The effect of four weeks of Echinacea supplementation on erythropoietin and indices of erythropoietic status. Medicine and Science in Sports and Exercise, 38(5), Supplement abstract 2256.
PURPOSE. This study determined whether four weeks of oral Echinacea purpurea supplementation resulted in alterations in erythropoietin, red blood cell count, hematocrit, or hemoglobin. Recreationally active males N = 24) were assigned randomly to either an Echinacea (N = 12) or a placebo (N = 12) group. Participants were supplemented for 28 consecutive days.
RESULTS. Serum erythropoietin was significantly greater in the Echinacea condition than in the placebo group at days, 7, 14, and 21.
CONCLUSION. Echinacea purpurea supplementation for 28 days promoted a significant increase in erythropoietin.
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4. Whitehead, M. T., Martin, T. D., Webster, M. J., & Scheett, T. P. (2005). Two weeks of oral Echinacea supplementation significantly increases circulating erythropoietin. Medicine and Science in Sports and Exercise, 37(5), Supplement abstract 231.
STUDY. Healthy active males (N = 24) were assigned randomly to a placebo or an Echinacea purpurea supplementation group. Subjects received 8 gm/day of one substance for 14 days.
RESULTS. Erythropoietin (EPO) was 44.15% greater in the supplemented group than in the placebo group.
CONCLUSION. Echinacea purpurea stimulates significant EPO increases.
Red Blood Cell Nutrients
Ingredients: Vitamin B-3 (Niacinamide), Vitamin B-6 (Pyridoxine HCl), Folate (Folic Acid), Vitamin B-12
(Cobalamin), Inositol, Boron
2. Agte VV, Paknikar KM, Chiplonkar SA (1997) Effect of nicotinic acid on zinc and iron metabolism.
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Iron Availability Complex
Ingredients: Iron, Vitamin C (Ascorbic Acid), Vitamin B-3 (Niacinamide), Nickel, Dandelion Extract,
Yellow Dock Extract
10. Koury MJ, Ponka P (2004) New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr. 24:105-31.
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Anti-Inflammatory Complex
Ingredients: Alpha-Lipoic Acid, Lutein, Lycopene, Choline, PABA
17. Zembron-Lacny A, Szyszka K, Szygula Z. (2007) Effect of cysteine derivatives administration in healthy men exposed to intense resistance exercise evaluation of pro-antioxidant ratio. J Physiol Sci. 57(6):343-8.
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